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High quality raw material lactulose Lactulose CAS No.:4618-18-2

High quality raw material lactulose Lactulose CAS No.:4618-18-2

Lactulose with CAS NO.: 4618-18-2 Basic Information Product name:Lactulose Other name:4-O-beta-D-Galactopyranosyl-alpha-D-fructose...
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  • High quality raw material lactulose Lactulose CAS No.:4618-18-2
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Product Description

Lactulose with CAS NO.: 4618-18-2

Basic Information

Product name:Lactulose
Other name:4-O-beta-D-Galactopyranosyl-alpha-D-fructose
Formula:C12H22O11
Molecular weight:342.30
CAS no:4618-18-2
Melting point :173-178 ºC
Specific Rotation :-47 º (C=5, H2O, 12HR)
Storage conditions:Refrigerator
Water Solubility:76.4 G/100 ML (30 ºC)
Density: 1,32g/cm

Introduction

Lactulose is a synthetic, non-digestible sugar used in the treatment of chronic constipation and hepatic encephalopathy, a complication of liver disease. It is a disaccharide (double-sugar) formed from one molecule each of the simple sugars (monosaccharides) fructose and galactose. Lactulose is not normally present in raw milk, but is a product due to the heat-processes: the more the heat, the more the presence of this substance (from 3.5 mg/l in low temperature pastorized milk to 744 mg/l in in-container sterilized milk).It is produced commercially by isomerization of lactose.

It is broadly classified as an osmotic laxative. It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.

Referance Specification

Identification

1) IR

Complies

2) HPLC

Complies

3) Sulfate

Complies

Water

≤0.5%

0.10%

Residue on Ignition

≤0.2%

0.08%

3) Residual solvents

Methanol: ≤0.3%

Acetone: ≤0.5%

Ethanol: ≤0.5%

0.12%

0.01%

Not detected

Assay

99.0~101.0% (calculated on anhydrous

and solvent free basis)

99.95%

Conclusion

The batch conforms to USP39 standard requirements


Usage:

Constipation
Lactulose is used in the treatment of chronic constipation in patients of all ages as a long-term treatment.
Lactulose is used for chronic idiopathic constipation, i.e. chronic constipation occurring without any identifiable cause. This is by far the most common finding.
Lactulose may be used to counter the constipating effects of opioids, and in the symptomatic treatment of hemorrhoids as a stool softener.
The dosage of lactulose for chronic ideopathic constipation is adjusted depending on the constipation severity and desired effect, from stool softening to a strong bowel movement. Dosage is reduced in case of galactosemia as most preparation contain the monosaccharide galactose due to its synthesis process. The dosage for an adult ranges from one to four tablespoons with breakfast and for children, one (five milliliter) teaspoon for each year of age up to age sixteen.

Hyperammonemia

Lactulose is useful in treating hyperammonemia (high blood ammonia). This can be caused by hepatic encephalopathy. Lactulose helps trap the ammonia (NH3) in the colon. It does this by using gut flora to acidify the colon, transforming the freely diffusible ammonia into ammonium (NH4+) which can no longer diffuse back into the blood. It is also useful for preventing hyperammonemia caused as a side effect of administration of valproic acid.
Lactulose for hepatic encephalopathy generally requires oral dosage three or four times a day with episodic diarrhea and constant flatulence almost a certain side effect. People who take lactulose at this level of dosage generally end up wearing an adult diaper and plastic pants for any activities away from home or at night (with a chux pad for the bed) because the diarrhea can occur swiftly and without much warning.

Small intestine bacterial overgrowth

Lactulose is used as a test of small intestine bacterial overgrowth (SIBO). Recently the reliability of it for diagnosing SIBO has been seriously questioned. A large amount of it is given with subsequent testing of molecular hydrogen gas in the breath. The test is positive if an increase in exhaled hydrogen occurs before that which would be expected by normal colonocyte digestion. An earlier result has been hypothesized to indicate digestion occurring within the small intestine. An alternate explanation for differences in results is the variance in small bowel transit time among tested subjects.

Packing(plastic woven bags lined with plastic bags)
25kgs pp woven bags with pe liner , 1000kgs jumbo bags, 25tons/20'Fcl

Storage

Lactulose should be stored in a cool, dry, well-ventilated area in tightly sealed containers.

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